Colchester will be without Tyreik Wright for the visit of Tranmere on Saturday.
The 20-year-old winger has been called up for international duty by the Republic of Ireland Under-21s in their upcoming European Championship qualifier with Sweden.
The U’s are also without Tommy Smith and Armando Dobra who are also away on international duty.
Defender Ryan Clampin remains out with a long-term knee injury.
Paul Glatzel will not be available for Tranmere boss Micky Mellon.
The 21-year-old forward had recently returned from injury but suffered a hamstring problem in Rovers’ 3-2 win over Mansfield a fortnight ago and is set to miss the rest of the season.
Midfielder Jay Spearing is continuing his recovery from injury but the weekend’s game may come too soon.
Fellow Midfielder Kieron Morris has also been injured since the Mansfield fixture and remains a doubt with a shoulder issue.
Subscribe or register today to discover more from DonegalLive.ie
Buy the e-paper of the Donegal Democrat, Donegal People's Press, Donegal Post and Inish Times here for instant access to Donegal's premier news titles.
Keep up with the latest news from Donegal with our daily newsletter featuring the most important stories of the day delivered to your inbox every evening at 5pm.