Oxford will be without James Henry for the visit of MK Dons in Sky Bet League One on Tuesday.
The midfielder suffered a fractured nose and gash to his forehead in a clash with Fleetwood captain Tom Clarke on Saturday, required plastic surgery and could miss the remainder of the season.
Sam Baldock is expected to remain sidelined with a knee problem.
Marcus Browne will join him with a hamstring injury.
MK Dons are likely to be without striker Mo Eisa.
Eisa went down in the second half of his side’s 3-2 defeat to Sheffield Wednesday and was carried off on a stretcher.
If the 27-year-old is unable to play, he could be replaced by Connor Wickham.
Manager Liam Manning will definitely be without Tennai Watson and Aden Baldwin.
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